PN vs PDRN: The Complete Guide to Polynucleotide Skin Rejuvenation (And Why European PN Is Becoming the New Gold Standard

Polynucleotide (PN) and Polydeoxyribonucleotide (PDRN) treatments have become some of the fastest-growing regenerative procedures in modern aesthetic medicine. If you’ve heard of Rejuran, PN Skin Booster, PN Eye, or Croma PolyPhil, you’ve already been exposed to this entire family of DNA-based therapies — but the differences between them are often misunderstood.

In Malaysia, Rejuran (PDRN) is widely known due to early marketing. But globally — especially in Europe — clinics and practitioners are increasingly switching to PN, a more advanced and potent form of DNA-based rejuvenation. While Rejuran (PDRN) is widely known for skin healing and glow, newer PN formulations are increasingly chosen for anti-aging and firmness.

This guide explains everything you need to know about PN vs PDRN, how they work, the science behind them, and why many aesthetic doctors consider European PN (Croma PolyPhil) the new standard for long-term, structural anti-aging.

⭐ What Are PN and PDRN? The Science, Explained Simply

To understand the difference, imagine DNA as a long chain. These chains can be broken down into fragments of different lengths.

PDRN = Shorter DNA Fragments (<1500 kDa)

Used mainly for:

• Healing

• Mild regeneration

• Anti-inflammatory effects

• Skin repair

This is the category Rejuran falls under.

PN = Longer DNA Fragments (>1500 kDa)

Used mainly for:

• Structural support

• Collagen stimulation

• Tissue remodeling

• Long-term anti-aging

These longer-chain PNs act as biological scaffolds, helping skin cells grow, organise, and regenerate more effectively.

⭐ PN vs PDRN: Key Differences at a Glance

Feature	PN (Polynucleotide)	PDRN (Polydeoxyribonucleotide)
Molecular size	Long-chain (>1500 kDa)	Short-chain (<1500 kDa)
Main function	Structural remodeling, collagen stimulation	Healing + repair
Clinical strength	Stronger anti-aging effect	Good for hydration + healing
Duration	Longer-lasting	Shorter duration
Swelling after injection	Smoother, lower swelling	More bumps (esp. around eyes)
Cost to produce	Higher (purification is complex)	Lower
Common brands	Croma PolyPhil, Plinest	Rejuran

In short: PDRN is excellent for healing —but PN goes one level higher by improving structure, firmness, and long-term collagen regeneration.

⭐ Why PN Is Becoming the Global Gold Standard (Especially in Europe)

In Europe, PN has been used for over 40 years in medical wound healing. Brands like Plinest and PolyPhil are widely respected because they follow European CE medical standards and use highly purified processes. For patients seeking deeper collagen regeneration and long-term skin strengthening, polynucleotide (PN) treatments offer structural rejuvenation beyond hydration-based skin boosters.

Doctors prefer PN because:

✔ It gives stronger lifting and firming

PN improves skin turgor, elasticity, and bounce in a way PDRN cannot match.

✔ Results last longer

Collagen-building means the skin gradually becomes stronger and thicker.

✔ It works better for anti-aging and scars

Ideal for:

• Fine lines

• Sagging

• Acne scars

• Neck aging

• Thin under-eye skin

✔ It integrates more smoothly into the skin

Unlike thicker PDRN formulations, PN causes less visible bumps post-procedure.

⭐ Croma PolyPhil PN: Europe’s Version of Plinest — Now in Malaysia

Most Malaysians know Rejuran because it came earlier into the Asian market.But the world’s original PN technology actually comes from Italy, by a pharmaceutical company called Mastelli.

Croma PolyPhil = Updated, modernized PN from Europe

• Formula derived from the same PN technology as Plinest

• Manufactured with HPT™ high-purity technology

• Distributed by Croma (Austria) — a world leader in regenerative injectables

This makes Croma PolyPhil a European-grade PN, backed by decades of clinical use.

⭐ Croma PN vs Rejuran: A Fair Comparison

This comparison helps your readers understand the positioning without sounding negative.

✔ 1. Source of DNA

• Croma PN: Trout DNA

• Rejuran: Salmon DNABoth are safe and purified.

✔ 2. Manufacturing Origin

• Croma PN: Italy (manufactured) + Austria (brand)

• Rejuran: South Korea

European medical devices have strict quality standards, which is a strong selling point.

✔ 3. Skin Feel and Downtime

• Croma PN = smoother, less swelling, gentler for eyes

• Rejuran = thicker, higher chance of bumps especially in the peri-orbital area

✔ 4. Result Type

Croma PN = Structural remodeling + firmness + anti-aging

Rejuran = Repair + hydration + glow

✔ 5. Which lasts longer?

PN generally gives longer-lasting structural improvements because it triggers collagen-building at a deeper

⭐ Who Should Choose PN?

PN is suitable for anyone who wants:

✔ Natural anti-aging

(not lifting artificially like fillers)

✔ Better skin texture and firmness

(common in people aged 25–60+)

✔ Acne scar improvement

PN supports dermal remodeling

✔ Anti-aging around the eyes

Especially thin skin that cannot tolerate fillers

✔ Regeneration after laser treatments

Heals faster + improves outcomes

✔ Long-term structural improvement

Ideal for people who want a “slow and steady” natural rejuvenation

⭐ Treatment Plan for PN

Most patients follow:

• Session 1:

Collagen activation begins

• Session 2 (4 weeks later):

Stronger firmness and hydration appear

• Optional Session 3 (Month 2):

Best for anti-aging or scars

• Maintenance: Every 6 months

Skin stays lifted, strong, and glowing with minimal downtime.

⭐ PN vs Skinboosters — They Are NOT the Same

Many patients confuse PN with HA (hyaluronic acid) skinboosters.

Skinboosters (HA):

• Hydration

• Dewy glow

• No collagen rebuilding

PN:

• Regeneration

• Collagen formation

• Structural strengthening

• Long-term anti-aging

Best results = Combination

Using PN + Skinboosters together can transform the skin much faster than either alone.

⭐ Before & After: What to Expect

Week 1:

• Improved hydration

• Smoother surface

• Reduced redness (if applicable)

Week 4:

• Tighter pores

• More glow

• Subtle firming

Week 8–12:

• Fine lines soften

• Skin thickens

• Natural lift

• Better elasticity

Improvement continues as collagen gradually builds.

⭐ Why RJ Clinic Uses Croma PN Instead of Rejuran

This section should be subtle but persuasive:

We choose Croma PolyPhil PN because:

✔ It is European-manufactured (Italy + Austria)

✔ Uses highly purified long-chain PN

✔ Offers smoother injection and lower swelling

✔ Proven for both anti-aging and structural remodeling

✔ More comfortable for the delicate eye area for the improvement of dark eye circle and periorbital rejuvenation post eyebag laser

✔ Ideal for acne scars due to stronger cross-linking effect

RJ Clinic performs PN treatments usingspecialised micro-injection techniques for minimal downtime.

⭐ Frequently Asked Questions

Is PN safe?

Yes. PN has been used in medical wound healing for over 40 years with an excellent safety profile.

Is it better than Rejuran?

Each has its strengths.Rejuran is great for healing; PN is better for long-term anti-aging.

How soon can I see results?

Most patients see improvements from Week 1 onwards, with the best results appearing at 8–12 weeks.

Does it hurt?

We use numbing + fine needles, making the procedure comfortable.

⭐ Conclusion: PN Is the Future of Regenerative Aesthetics

PDRN healed the skin.PN rebuilds the skin.

With stronger collagen stimulation, longer chains, and European pharmaceutical standards, Croma PolyPhil PN has quickly become the preferred choice for patients who want natural, long-lasting rejuvenation.

If you’re looking for:

✓ Firmer skin

✓ Better elasticity

✓ Stronger collagen

✓ Healthier under-eye area

✓ A youthful, natural appearance

PN may be the right choice for you.

📞 Book Your Polynucleotide Treatment at RJ Clinic

RJ Clinic (Segambut • Ativo Plaza • Eco Santuari)

📱 WhatsApp us for consultation: +6018 5751353

💎 Expert doctors 

• Authentic European PN • Natural, structural rejuvenation